Microzide is a moderate thiazide diuretic medication which decreases reabsorption of Na+ at the level of cortical limb of Henle's' loop not influencing its segment located in the medullary layer of the kidney. This is a reason for its weaker diuretic effect comparing to Lasix. Microzide is used to treat high blood pressure and accumulation of fluid (oedema of different origin). Mechanism of its treating effect on lowering of high blood pressure is not well understood.
Dosage and direction
Microzide may be taken with or without food and its dose depends on your condition, age and weight and should be prescribed by your doctor.
Avoid drinking alcohol, becoming overheated or dehydrated during workouts, exercise and in hot weather. Warn your doctor if you suffer from liver disease, kidney disease, asthma or allergies, gout, diabetes, or if you are allergic to sulfa drugs.
Hypersensitivity, diabetes, chronic kidney failure, anuria, severe liver failure Addison disease, the first trimester of pregnancy, breastfeeding, infancy (younger than 3 y.o.).
Possible side effect
If you feel weakness, low blood pressure, light sensitivity, impotence, nausea, abdominal pain, electrolyte disturbances, pancreatitis, jaundice, anaphylaxis, and rashes contact your doctor and seek for immediate medical help. Patients allergic to Sulfa may also be allergic to Microzide. Microzide can aggravate kidney dysfunction, lower blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to abnormalities in heart rhythm, so treatment with Microzide require supplementation with potassium is common to prevent low potassium levels.
Concomitant treatment with ethanol, barbiturates, opioid analgesics increases the risk of hypotension. If Microzide is administered with insulin and medications which decrease levels of sugar in blood correction of such medication may be needed. Microzide reduces the elimination of lithium by the kidneys. Nonsteroidal anti-inflammatory drugs may reduce the blood pressure effects of Microzide.
If you forgot to take a dose take it as soon as you remember. Skip the missed dose if it is almost time for the next intake. Resume your regular schedule. Do not compensate for the missed dose by taking an extra one.
If you experience nausea, weakness, dizziness, dry mouth, thirst, and muscle pain or weakness seek for immediate medical help.
Keep at room temperature, 15-30 C (59-86 F), in a light-resistant container away from moisture.