Calan is a Ca2+-channel blocker which relaxes (widens) veins and arteries, which makes it easier for the heart to pump and this way Calan reduces its workload. Calcium triggers contraction of smooth muscles and when its entrance to the myocytes, it results in relaxation of the arterial muscles, improved oxygen delivery to the myocardial tissue, and decreased total peripheral resistance, systemic blood pressure, and after-load. Calan also decreases the conduction of electrical impulses through the heart that control the coordination of contraction, this slows the rate of contraction. Calan is used to treat hypertension, to treat angina, control some types of irregular heartbeats.
Take orally with or without food. Daily dose is 180-480 mg which may be taken as a single dose or divided in two or three intakes. Take exactly as prescribed by your doctor, never exceed the dose recommended to you.
Calan is contraindicated in patients with hypersensitivity to components of the medication, severe left ventricular dysfunction, hypotension (systolic pressure less than 90 mm Hg) or cardiogenic shock, sick sinus syndrome (except in patients with a functioning artificial ventricular pacemaker), atrioventricular block degree II-III (except in patients with a functioning artificial ventricular pacemaker), atrial flutter or atrial fibrillation and an accessory bypass tract (Wolff-Parkinson-White, Lown-Ganong-Levine syndromes).
Arpamyl is usually well tolerated. Most common side effects include
weakness or fainting,
swelling of the lower extremities,
Jaundice, swelling, difficulty breathing, rashes are also possible.
If you experience severe side effects listed above seek for immediate medical attention.
Take the dose you forgot as soon as you remember. If it is almost time for your next intake just skip the next dose and return to your regular schedule.
If you experience slow heartbeat and fainting, they may be symptoms of overdose. Seek for immediate medical attention if you suppose that too much of Calan was taken.
Store at room temperature 15-30 C (59-86 F) away from light, moisture, pets and children.